TMS adaptable auditory control - a universal tool to deal with TMS-evoked auditory potential

Abstract Coupling transcranial magnetic stimulation with electroencephalography (TMS-EEG) allows recording the EEG response to a direct, non-invasive cortical perturbation. However, obtaining genuine TMS-evoked potentials (TEPs) requires controlling for several confounds, including auditory evoked (AEPs) associated TMS discharge noise (TMS click). To rule out AEPs from TEPs, AEP can be mathematically removed contaminated TEP through off-line pre-processing, or early prevented by masking click during TEPs acquisition. Although more effective, use of latter is limited due risks delivering loud noises subjects. We tested and released Adaptable Auditory Control (TAAC), an open-source Matlab®-based tool that users generate customized designed on coil-specific click. Notably, create tailored subject-specific perception, TAAC mixes manipulates in time frequency domains two standard used literature (i.e., white adapted Here we compared generated both population 20 healthy subjects quantifying sound pressure level (SPL, dB, measured Head Torso Simulator) required mask Both were effective at safe lower SPLs respect noises, according safety guidelines. By minimizing loudness, generates each device single individuals. Associating real-time visualization waveforms help control procedure’s effectiveness non-compliant patients. Finally, highly flexible tool, so its applicability extended meet different experimental setups may affected acoustic startle responses, such as TMS-electromyography. Research Category Technology Methods Basic Research: 10. Transcranial Magnetic Stimulation (TMS) Keywords: potentials, Noise Masking, TMS-EEG,